ES2031509T3 - Un procedimiento para la preparacion de agentes antiarritmicos. - Google Patents

Un procedimiento para la preparacion de agentes antiarritmicos.

Info

Publication number
ES2031509T3
ES2031509T3 ES198787306922T ES87306922T ES2031509T3 ES 2031509 T3 ES2031509 T3 ES 2031509T3 ES 198787306922 T ES198787306922 T ES 198787306922T ES 87306922 T ES87306922 T ES 87306922T ES 2031509 T3 ES2031509 T3 ES 2031509T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
antiarrhythmic agents
alkyl
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787306922T
Other languages
English (en)
Spanish (es)
Inventor
John Edward Glyn Kemp
Peter Edward Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of ES2031509T3 publication Critical patent/ES2031509T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
ES198787306922T 1986-08-09 1987-08-05 Un procedimiento para la preparacion de agentes antiarritmicos. Expired - Lifetime ES2031509T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619472A GB8619472D0 (en) 1986-08-09 1986-08-09 Anti-arrhythmia agents

Publications (1)

Publication Number Publication Date
ES2031509T3 true ES2031509T3 (es) 1992-12-16

Family

ID=10602501

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787306922T Expired - Lifetime ES2031509T3 (es) 1986-08-09 1987-08-05 Un procedimiento para la preparacion de agentes antiarritmicos.

Country Status (11)

Country Link
US (1) US4797401A (en])
EP (1) EP0257864B1 (en])
JP (1) JPS6344572A (en])
AT (1) ATE58898T1 (en])
DE (1) DE3766570D1 (en])
DK (1) DK169129B1 (en])
ES (1) ES2031509T3 (en])
GB (1) GB8619472D0 (en])
GR (1) GR3001231T3 (en])
IE (1) IE60030B1 (en])
PT (1) PT85506B (en])

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
DE3933163A1 (de) * 1988-10-27 1990-05-03 Toyoda Gosei Kk Zylindrische daempfungsbuchse
US5033872A (en) * 1989-09-06 1991-07-23 Toyoda Gosei Co., Ltd. Bushing
US5051422A (en) * 1989-09-15 1991-09-24 Schering Ag 2-substituted-1(4)-aryl piperazines and the process for their preparation
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
CN110156729B (zh) * 2019-05-14 2022-12-06 浙江大学 一种苯基哌嗪类ube2f小分子抑制剂及其合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB997166A (en) * 1961-07-14 1965-07-07 May & Baker Ltd N-phenylpiperazine derivatives
BE654017A (en]) * 1963-04-04 1965-04-06
ES291187A1 (es) * 1963-04-04 1964-01-16 American Cyanamid Co Un procedimiento para preparar piperazinas sustituidas
US3331845A (en) * 1963-04-04 1967-07-18 American Cyanamid Co 1-substituted-4-substituted amino alkylene piperazines
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
US3822266A (en) * 1968-12-24 1974-07-02 Hoffmann La Roche (3-(1-piperazinyl)-2-hydroxy-propoxy)acetanilides
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
US3764602A (en) * 1969-12-04 1973-10-09 Hoffmann La Roche 3-(4-phenyl-1 2, 6 di keto piperazinyl)-2-hydroxy-propoxy)-aniline
US3930004A (en) * 1970-11-10 1975-12-30 Pfizer Method of using phenoxypropanolpiperazine compounds to lower blood pressure
GB1361863A (en) * 1972-09-25 1974-07-30 Pfizer Ltd Piperazine derivatives their preparation and pharmaceutical compositions containing them
FR2515648A1 (fr) * 1981-11-03 1983-05-06 Cortial Nouvelles (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof

Also Published As

Publication number Publication date
IE60030B1 (en) 1994-05-18
ATE58898T1 (de) 1990-12-15
GB8619472D0 (en) 1986-09-17
JPH0567150B2 (en]) 1993-09-24
DK411687A (da) 1988-04-28
EP0257864B1 (en) 1990-12-05
PT85506B (pt) 1990-06-29
EP0257864A1 (en) 1988-03-02
IE872120L (en) 1988-02-09
US4797401A (en) 1989-01-10
JPS6344572A (ja) 1988-02-25
PT85506A (en) 1987-09-01
DK169129B1 (da) 1994-08-22
GR3001231T3 (en) 1992-07-30
DK411687D0 (da) 1987-08-07
DE3766570D1 (de) 1991-01-17

Similar Documents

Publication Publication Date Title
ES2031509T3 (es) Un procedimiento para la preparacion de agentes antiarritmicos.
ES2077806T3 (es) Derivados de isoxazol, procedimiento para su preparacion y sus aplicaciones herbicidas.
BG41820A3 (en) Method for preparing n- (3- hydroxy- 4- piperidinyl) benzamide derivatives
ES2138691T3 (es) Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina.
ES2033423T3 (es) Procedimientos para preparar derivados de 2-fenilpurinona.
ES8801277A1 (es) Procedimiento para preparar (1,2,4) triazolo (1,5-c) quinazolinas
ES2084831T3 (es) Nuevo procedimiento para preparar formoterol y compuestos relacionados.
ES2037665T3 (es) Procedimiento para la preparacion de compuestos heterociclicos que contienen n.
ES557514A0 (es) Procedimiento para la obtencion de acidos 1-ciclopropil-1,4-dihidro-4-oxo-1,8-naftiridin-3-carboxilicos
DK55683A (da) Fungicide indanylbenzamider samt fremgangsmaade til fremstilling heraf
ES515724A0 (es) Procedimiento para la obtencion de derivados de fenilsulfonil-urea sustituidas.
DK291488D0 (da) Alkansulfonanilidderivater
ES2090012T3 (es) Derivados de propoxibenceno y procedimiento para la preparacion de los mismos.
MX9301404A (es) Derivados de 2-oxoquinolina, procedimiento para su preparacion, preparado farmaceutico que los contiene y procedimiento para la obtencion de tal preparado farmaceutico.
ES462173A1 (es) Procedimiento para la preparacion de derivados de acido 7-a-cilamino-8-oxo-3-oxa-1-azabiciclo-(4,2,0)-octan-2-carboxili-co.
ES545004A0 (es) Un procedimiento para producir un acetileno.
ES2037135T3 (es) Procedimiento para la obtencion de 5-amino-pirazoles substituidos y los fungicidas que les contienen.
ES2046496T3 (es) Procedimiento para la preparacion de agentes de hidroxialquilacion, los nuevos agentes asi obtenidos y su empleo.
ES8603416A1 (es) Un procedimiento para preparar derivados de dihidropiridina
ES8201979A1 (es) Procedimiento para la obtencion de derivados de bifeni- lil-azoliletano
ES2001670A6 (es) Procedimiento para preparar derivados de fenoxiftalida y composiciones herbicidas que los contienen
ES8702392A1 (es) Un procedimiento para preparar compuestos heterociclicos, en particular compuestos con un anillo de tiadiazinona
MX9300133A (es) Nuevas pirido [2,3-d]piridazin-5-onas y pirido [2,3-d] piridazin-5-tionas, procedimiento para su preparacion y composiciones herbicidas que las contienen.
ES2053544T3 (es) Un procedimiento para la preparacion de nuevos derivados de indol tetraciclicos.
AR221712A1 (es) Procedimiento para preparar compuestos de 9-amino-o 9-piridinio-6-alquil(c1-4)-4-oxo-6,7-dihidro-o-6,7,8,9,-tetrahidro-4h-pirido-(1,2-a)pirimidina y sus sales

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 257864

Country of ref document: ES